1778 Results for: "Smoothened+agonist"

Supplier: Apollo Scientific

Smoothened agonist

Supplier: Abcam

Potent Smo activator (EC₅₀ = 3 nM, NIH 3T3-derived Shh-LIGHT2 cells). Interacts with the heptahelical domain (Kd = 59 nM). Behaves as an activator at low concentrations and as an inhibitor at high concentrations. Water soluble version of SAG.

Supplier: Abcam

Heterobifunctional photoreactive (at 320 to 350 nm), long arm (18.2 angstrom) primary amine-nitrophenylazide crosslinker. NHS-ester containing crosslinking agent. Contains a photosensitive phenyl azide group on one end and an amine-reactive N-hydroxysuccinimide on the other.

Supplier: Abcam

Potent, selective TGR5 G-protein coupled receptor agonist (pEC₅₀ = 6,8). Increases glucagon-like peptide-1 (GLP-1) secretion from primary intestinal cells. Cell-permeable. Active in vivo.

Supplier: Abcam

Inactive Tubacin (HDAC6 inhibitor) analog and negative control. Achieve your results faster with highly validated, pure and trusted compounds.

Supplier: US Biological

Anti-Smoothened Rabbit Polyclonal Antibody

Supplier: US Biological

Anti-Smoothened Rabbit Polyclonal Antibody

Supplier: Biorbyt

Anti-Smoothened Rabbit Polyclonal Antibody

Supplier: Biorbyt

Anti-Smoothened Rabbit Polyclonal Antibody

Supplier: Abcam

Rabbit polyclonal to Smoothened.

Supplier: Bioss

G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.

Supplier: Abcam

Rabbit Polyclonal Smoothened antibody. Suitable for WB, IF, IHC-P and reacts with Rat samples. Cited in 19 publications. Immunogen corresponding to Synthetic Peptide within Human SMO aa 500-600.

Supplier: Abcam

Rabbit Polyclonal Smoothened antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 2 publications.

Supplier: Biorbyt

Anti-Smoothened Rabbit Polyclonal Antibody (FITC (Fluorescein))

Supplier: Abcam

Recombinant Human Smoothened protein is a Human Fragment protein, in the 653 to 787 aa range, expressed in Wheat germ and suitable for SDS-PAGE, ELISA, WB.

Supplier: Bioss

G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.

Supplier: Abcam

mGlu Agonists Kit (ab120321) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.

Supplier: Abcam

Ionotropic Agonists Kit (ab120323) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.

Supplier: Abcam

Potent Smoothened antagonist (IC₅₀ = 5,8 nM). Blocks Hedgehog signaling in cell-based assays. Inhibits Gli1 and PTCH1 expression in cell lines. Reduces proliferation and induces apoptosis in tumour cellls.

Supplier: Abcam

Selective PPARγ agonist (EC₅₀ = 43 nM). Thiazolidinedione. Mediates adipocyte differentiation, increases lipogenesis and enhances fatty acid and glucose uptake. Promotes differentiation of urothelial organoids; potent and selective PPARγ agonist.

Supplier: Abcam

Selective group I mGlu agonist. Achieve your results faster with highly validated, pure and trusted compounds.

Supplier: Abcam

Endogenous progesterone receptor agonist (EC₅₀ = 0,5 nM) C-21 steroid hormone. Elicits a variety of biological effects.

Supplier: Abcam

Potent GPR120 (free fatty acid receptor 4; FFAR4) agonist (pEC50 values are 7,36 and 7,77 for human and mouse GPR120 respectively). Selective for GPR120 over free fatty acid receptors (pEC50 = 4,19 for FFA1; displays no activity at FFA2 or FFA3).

Supplier: Abcam

Partial agonist at the NMDA receptor glycine recognition site. Enhances learning and memory in vivo. Perfomance enhancer in a variety of cognitive models. Also available in simple stock solutions - add 1 ml of water to get an exact, ready-to-use concentration.

Supplier: Abcam

MW 569.66 g/mol, Purity >95%. Synthetic δ-opioid peptide agonist, with some activity at μ-opioid receptors. Neuro- and tissue-protective properties. Attenuates mRNA expression of p53 and c-fos.

Supplier: Abcam

MW 777.96 g/mol, Purity >95%. Potent and selective PAR₂ receptor agonist (EC₅₀ = 340 nM). Induces arterial contraction. Facilitates capsaicin evoked nociception. Around 100 times more potent than SLIGR-NH₂ (ab120176).

Supplier: Abcam

DAMGO, mu opioid receptor agonist. Achieve your results faster with highly validated, pure and trusted compounds.

Supplier: Abcam

Peripheral selective μ opioid receptor agonist. Ki values are 3, 48 and 1156 nM for opioid receptor subtypes μ, δ and κ, respectively. High doses allow central μ receptor activation. Antidiarrheal, antipruritic and antihyperalgesic agent.

Supplier: Abcam

MW 782.89 g/mol. Selective δ opioid receptor agonist (Ki values are 1.5, >1000 and >1000 nM for opioid receptor subtypes δ, μ and κ, respectively). Antinociceptive activity. Centrally active following intravenous administration.

Supplier: Abcam

Potent thromboxane A2 agonist (EC50 = 35 nM). Activates p38, ERK-1 and ERK-2. Induces platelet aggregation and shows vasoconstrictive effects *in vivo.*.