- Antibody type:Primary
- Antigen name:BCL2 binding component 3
- Antigen symbol:BBC3
- Clonality:Monoclonal
- Clone:10C5G1
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- Reactivity:Human,Rat
- Western blot:Yes
- Format:Purified Antibody
- Form:Liquid
- Gene ID:27113
- Antigen synonyms:PUMA Antibody [10C5G1] : JFY1, PUMA, JFY-1
- Storage temperature:PUMA monoclonal antibody can be stored at -20˚C, stable for one year.
- Concentration:1 mg/mL
- Shipping temperature:4°C
- Immunogen:Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
- Purification:PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG.
- Size:100 μg
- Pk:100 µG
PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
PUMA antibody can be used for detection of PUMA by Western blot at 2.5 to 5 μg/mL.
Type: Primary
Antigen: BBC3
Clonality: Monoclonal
Clone: 10C5G1
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype:
Reactivity: Human, Rat