Anti-ALS2 Rabbit Polyclonal Antibody (Cy3®)

Fornitore: Bioss
Anti-ALS2 Rabbit Polyclonal Antibody (Cy3®)
Mutations in the ALS2 gene result in a number of juvenile recessive motor neuron diseases (MNDs), including juvenile primary lateral sclerosis (JPLS), a recessive form of amyotrophic lateral sclerosis (ALS2); infantile onset ascending hereditary spastic paralysis (IAHSP); and a form of complicated hereditary spastic paraplegia (cHSP). The ALS2 gene encodes the Alsin protein. Alsin acts as a guanine nucleotide exchange factor for Rab5, a modulator of the endocytic pathway. Alsin is a cytosolic protein that is associated with small, punctate membrane structures. Therefore, Alsin may mediate membrane transport events, potentially linking endocytic processes and actin cytoskeleton remodeling. The ALS2 C-terminal-like protein (ALS2CL) also modulates Rab 5 activity.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: ALS2
Clonality: Polyclonal
Conjugation: Cy3®
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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