Anti-AIP1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Fornitore: Bioss
Anti-AIP1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
AIP1 (ASK-interacting protein 1), also known as DAB2IP (DAB2 interacting protein), is a 1,189 amino acid protein that localizes to both the membrane and the cytoplasm and contains one Ras-GAP domain, one PH domain and one C2 domain. Expressed at low levels in prostate tissue, AIP1 functions as a Ras GTPase-activating protein that interacts with ASK 1 and, via this interaction, disrupts the association of ASK 1 with an inhibitory 14-3-3 complex, thereby allowing free ASK 1 to function within the cell. AIP1 exists as multiple alternatively spliced isoforms and is down-regulated in prostate cancer tissue, suggesting a role in tumor suppression. Chromosomal aberrations in the gene encoding AIP1 are associated with acute myeloid leukemia (AML), implicating a role for AIP1 fusion proteins in tumorigenesis.

Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500

Type: Primary
Antigen: AIP1
Clonality: Polyclonal
Conjugation: HRP (Horseradish Peroxidase)
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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