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Anti-CCND2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Fornitore: Bioss
BOSSBS-1148R-A555EA 866 EUR
BOSSBS-1148R-A555
Anti-CCND2 Rabbit Polyclonal Antibody (Alexa Fluor® 555)
Anticorpi
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Recommended Dilutions: IF(IHC-P): 1:50-200; IF(ICC)(1:50-200

Type: Primary
Antigen: CCND2
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 555
Epitope:
Host: Rabbit
Isotype: IgG1
Reactivity: Human, Mouse, Rat
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