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Anti-APBA1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Fornitore: Bioss
BOSSBS-11334R-A350EA 858 EUR
BOSSBS-11334R-A350
Anti-APBA1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)
Anticorpi
The Beta-Amyloid precursor protein (Beta-APP) is a major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the ∫-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing Beta-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of Beta-APP. Multiple splice varitents of X11 have been identified, including X11å (also designated Mint 1), X11Beta (Mint 2) and X11(Mint 3).

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: APBA1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 350
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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