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Anti-ATXN7 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Fornitore: Bioss
BOSSBS-11318R-A488EA 858 EUR
BOSSBS-11318R-A488
Anti-ATXN7 Rabbit Polyclonal Antibody (Alexa Fluor® 488)
Anticorpi
The human ataxin-7 gene, also known as spinocerebellar ataxia 7 or SCA7, maps to chromosome 3p13-p12, has a 2,727-bp open reading frame, and encodes a 892 amino acid protein containing a nuclear localization signal and a polyglutamine tract (1,2). SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product (3,4). Ataxin-7 is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype (5). Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function (6).

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: ATXN7
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 488
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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