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Anti-CASP12 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Fornitore: Bioss
BOSSBS-1105R-A647EA 866 EUR
BOSSBS-1105R-A647
Anti-CASP12 Rabbit Polyclonal Antibody (Alexa Fluor® 647)
Anticorpi
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011].

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: CASP12
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 647
Epitope:
Host: Rabbit
Isotype: IgG1
Reactivity: Mouse, Rat
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