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Anti-DTX1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Fornitore: Bioss
BOSSBS-0399R-A555EA 858 EUR
BOSSBS-0399R-A555
Anti-DTX1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)
Anticorpi
Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

Recommended Dilutions: IF(IHC-P): 1:50-200

Type: Primary
Antigen: DTX1
Clonality: Polyclonal
Clone:
Conjugation: Alexa Fluor® 555
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat
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