- Antibody type:Primary
- Antigen name:Frizzled-Related Protein
- Antigen symbol:FRZB
- Clonality:Polyclonal
- ELISA:Yes
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Western blot:Yes
- Form:Lyophilized
- Gene ID:2487
- Antigen synonyms:FRZB-PEN|hFIZ|SFRP3|FRP-3|OS1|FRE|FRITZ|FZRB|FRZB1|SRFP3|FRZB-1
- UniProtKB:Q92765
- Storage temperature:At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.
- Immunogen:E.coli-derived human FRZB recombinant protein (Position: E176-N325). Human FRZB shares 90% amino acid (aa) sequence identity with mouse FRZB.
- Purification:Immunogen affinity purified.
- Size:100 µg/vial
- Pk:100 µG
Rabbit IgG polyclonal antibody for Secreted frizzled-related protein 3(FRZB) detection. Tested with WB, ELISA in Human.
FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. FRZB is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. FRZB is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling.
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
WB: The detection limit for FRZB is approximately 0.1ng/lane under reducing conditions.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
Type: Primary
Antigen: GRIN2B
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Rat
, Human