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Anti-BECN1 Rabbit Polyclonal Antibody

Fornitore: Thermo Scientific
Suggested positive control: antigen standard for BECN1 (transient overexpression lysate). Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biologic processes in which autophagy is important such as cell differentiation and nutritional stress responses.

Type: Primary
Antigen: BECN1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse



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Taglia Conf Codice catalogo VWR Quantità
100 µL 100 µl PIEAPA116939 Blocked
Codice articolo fornitore:: PA116939
Codice articolo locale:: PIEAPA116939
Blocked Questo prodotto è stato bloccato dalla vostra organizzazione. Si prega di contattare il vostro responsabile acquisti per ulteriori informazioni.

Specifiche

Antigene BECN1
Nome antigene Beclin 1
Reattività Mouse, Human
Coniugazione Unconjugated
Clonabilità Polyclonal
Tipo anticorpo Primary
Host Rabbit
Isotipo IgG
Western Blot Yes
Immunofluorescenza Yes
Sinomini antigene Beclin1 autophagy antibody., CTIP-1 COUP-TF interacting protein 1 antibody
ID gene 56208, 8678
Formato whole serum
Immunogeno Full-length human Beclin 1 protein.
Forma Liquid
Tampone di conservazione whole serum, 0.1% sodium azide
Temperatura di conservazione 4° C, do not freeze
Temperatura di spedizione Ice
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