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Anti-LC3 Rabbit Polyclonal Antibody

Fornitore: Thermo Fisher Scientific
PIEAPA116930EA 0 EUR
PIEAPA116930
Anti-LC3 Rabbit Polyclonal Antibody
Anticorpi
The reaction with mouse LC3 is weaker than human. The immunogen for this antibody production has 100% sequence homology with rat and zebrafish, 92% with mouse, and 91% with bovine proteins. LC3, a mammalian homologue of Apg8, was originally identified as microtubule-associated protein 1 light chain 3. It is a component of both the MAP1A and MAP1B microtubule-binding domains and the heavy-chain independent regulation of LC3 expression might modify MAP1 microtubule-binding activity during development. However, LC3 is now thought to also be involved in autophagy. LC3-I is cytosolic and LC3-II is membrane bound and enriched in the autophagic vacuole fraction. LC3-II is the first mammalian protein identified that specifically associates with the autophagosome membranes.

Type: Primary
Antigen: LC3
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Hamster, Primates, Canine, Bacteria, Bovine, Human, Rat, Porcine, Mouse, Zebrafish
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