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Anti-CD204 Rabbit Polyclonal Antibody

Fornitore: Thermo Scientific

Suggested positive control: antigen standard for MSR1 (transient overexpression lysate), mouse liver lysate, mouse liver protein. Macrophage scavenger receptors (MSR) are membrane glycoproteins that mediate the recognition and uptake of a wide variety of negatively charged macromolecules. There are two types of these receptors that differ in the C-terminal region. MSR has a key role in scavenging a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of MSR is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Ab deposition in Alzheimer's disease (AD).The observation that the 4 allele of the apolipoprotein E gene is associated with an increased risk for AD has lead to the investigation of lipoprotein metabolism in the brain of AD patients. The type I MSR has been found to be expressed on microglia and Mato cells, but not astrocytes or neurons. In AD brain, MSR type I is strongly expressed by microglia cells that are associated with senile plaques. Because the senile plaques contain AGEs, which are a source of free radicals that could result in oxidative damage to the brain, MSR may have a role in mediating the endocytosis of AGEs.

Type: Primary
Antigen: CD204
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Primates, Human



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Taglia Conf Codice catalogo VWR Quantità
100 µL 100 µl PIEAPA116825 Blocked
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Specifiche

Antigene CD204
Nome antigene Macrophage Scavenger Receptor 1
Reattività Human, Primates
Coniugazione Unconjugated
Clonabilità Polyclonal
Tipo anticorpo Primary
Host Rabbit
Isotipo IgG
Western Blot Yes
Immunofluorescenza Yes
Sinomini antigene MSR, MRS-A, SR-AI, MSR1, Scara1, Scvr, MSR-A, SR-AII
ID gene 4481
Concentrazione 0.97 mg/ml
Immunogeno A synthetic peptide made to an internal portion of the human MSR protein sequence (between residues 300-400). UniProt P21757
Purificazione Antigen affinity chromatography
Forma Liquid
Tampone di conservazione tris glycine, 150mM NaCl, 0.05% sodium azide
Temperatura di conservazione Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Temperatura di spedizione Ice
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