Specifiche
- Antibody type:Primary
- Antigen name:Double homeobox 4
- Antigen symbol:DUX4
- Clonality:Monoclonal
- Clone:P4H2
- Conjugation:Unconjugated
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG1
- Reactivity:Human
- Western blot:Yes
- Form:Liquid
- Gene ID:100653046
- Antigen synonyms:double homeobox protein 10|DUX10|double homeobox protein 4/10|double homeobox protein DUX10|double homeobox protein 4
- Storage buffer:PBS, 0.02% sodium azide
- Storage temperature:Store at 4 °C short term. For long term storage, store at –20 °C, avoiding freeze/thaw cycles.
- Concentration:1 mg/ml
- Shipping temperature:Ice
- Immunogen:Synthetic peptide corresponding to the C-terminal of human DUX4.
- Purification:Protein G
- Size:100 µL
- Pk:100 µl
Specifiche
Informazioni su questo articolo
DUX4 (also known as Double homeobox 4) is the leading candidate causative gene for facioscapulohumeral dystrophy (FSHD), a degenerative skeletal muscle disease and one of the most common muscular dystrophies. FSHD is caused by the deletion of a subset of D4Z4 macrosatellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4. DUX4 expression is epigenetically suppressed in differentiated tissues and the residual DUX4 transcripts are spliced to remove the carboxyterminal domain that has been associated with cell toxicity. In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle, and possibly other differentiated tissues, and results in a small percentage of cells expressing relatively abundant amounts of the full-length DUX4 mRNA and protein. [Snider et al. (2010) PLoS Genetics.6(10): e1001181]
Type: Primary
Antigen: DUX4
Clonality: Monoclonal
Clone: P4H2
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human